Episode Transcript
[00:00:02] Speaker A: Welcome my outside the box thinkers to the Anti Aging Unraveled podcast where I am your host, Dr. Lori Gerber. In this podcast, we will explore the fascinating world of personalized anti aging medicine that considers the whole person inside and out and how all systems are interconnected to each other. In today's world of modern medicine, we often find ourselves like just another number in a system that prioritizes quick fixes over sustainable and more natural solutions.
[00:00:32] Speaker B: Well, let's get ready for a paradigm.
[00:00:34] Speaker A: Shift in health and beauty. We look far beyond treating symptoms and aim to get to the root cause of our health and cosmetic issues. This podcast is your go to source for all things natural, outside the box, and innovative in integrative medicine and cosmetic dermatology. So sit back, relax and get ready to dive deep into the world of functional medicine and aesthetics with me, Dr. Lori Gerber.
Let's take a trip down the real skin revolution pathway together.
[00:01:05] Speaker B: Hello everybody and welcome back to the Anti Aging Unraveled podcast. I'm your Host as usual, Dr. Lori Gerber, and I'm here, as promised, giving you a second peptide conversation. It seems to be a very hot topic these days and in all honesty, it seems like everyone is loving the first podcast, so I come to bring you more podcast information. So we're going to talk about four different peptides today. And those four peptides are really about longevity and regeneration. You know, as part of our programming, we talk about life Jevity, which is health span meets longevity. And it gives you a framework, if you will, for extending lifespan and feeling better longer. So that's the peptides we're going to talk about today.
I like to say it's where longevity meets age your way, which is kind of our platform and our and our slogan. So we're going to dive into these four platforms, or four peptides, sorry, that redefine what is possible for energy, fat metabolism, sleep and brain optimization. So without kind of laboring the point, let's start talking about the first one. The first peptide is called AOD9604, called the metabolic modulator or the metabolism modulator. And it's really interesting. This one is just starting to become popular, at least with some of my patients. And it's a small piece or a fragment of human growth hormone. So human growth hormone is like the master peptide or the master hormone. It tells everybody downstream what to do. It's designed to trigger fat metabolism effects without raising some of the things that go up with human growth hormone. So for specifically for my people that maybe aren't Exercising as much as they want to or could they don't really want the anabolic effects of that HGH. AOD9604 can have that belly fat removal kind of focus without causing that unwanted tissue growth or increased muscle mass. It also literally, specifically type. It basically focuses on the belly fat, so stimulates fat breakdown and inhibits new fat formation. Maybe that's even more important than stimulating that fat breakdown. It stops the formation of new fat. Used best in the morning as most peptides. I like it better as an injection and it supports that weight, muscle tone and recovery. So it will help like kind of like growth hormone with that muscle tone and recovery and may enhance metabolic flexibility so that insulin resistance as well as some repair mechanisms and joint repair. So it is the perfect peptide for metabolic patients for someone who's plateauing in diet and exercise, maybe also as an adjunct to those GLP1s. If it's not working really well, or if you're plateaued, you're stuck or you can't get rid of that last little bit of belly fat. The great part about this peptide too, guys, is it's not a stimulant, so it's not going to cause that racy effect or anything like that. And really it won't affect blood sugar levels. So whereas some of the GLP1s really make your blood sugar drop and they're not very well tolerated by certain people because it makes them too tired, this AOD 9604 will actually get the fat without lowering blood sugar, which is pretty huge. And like I said, it can be used in conjunction or as like a little cohort to the GLP1s. So specifically focus on the abdomen. I can't say that it doesn't get rid of fat other places because it does, but it really does focus on that fat. Abdominal belly fat, perimenopausal, andropausal, male and female section. Very few side effects to this peptide. And it is taken again just like most of our peptides. This peptide is one of those peptides that we can, we can dose it a little bit differently, but we like to dose it five days a week. It can also be dosed weekly or bi weekly if you're kind of tapering down on a GLP1. So we do it like that as well.
Okay, let's talk about the next one. Epitalon. Epitalon is the longevity peptide. This is actually one of my favorite peptides. Why do I like this peptide so much? Because it doesn't have to be taken Every day, number one. Number two, it naturally stimulates the lengthening or the maintenance of telomeres. Telomeres are actually the basically the entails of DNA that actually start to degrade as we age.
And we think that this is one of the mechanisms of cellular aging and healthful and being healthier. Having longer telomeres, we think is a positive thing. So this stops the degradation and maintains the length of telomeres. And it can be. It actually can help with circadian rhythm. So your sleep and wake cycle enhances melatonin secretion and reduces oxidative stress in the mitochondria. So again, we're going back to that cellular, clean out that cellular debris. All this stuff that gets junked up on our mitochondria can't reverse things that are creating damage. And so, like oxidative stress, you know, various things that assault our body on a regular basis. This epital actually help to minimize that and actually reset that mitochondria. So that's why we call it the longevity peptide. Works on your telomeres of your DNA and it helps to enhance that mitochondrial repair and how they function. Obviously, the sleep, wake cycle and melatonin is a bonus. I mean, we know that sleep is so important for lifespan and healthspan, but we know the cells are functioning better. They're going to have a better cellular lifespan and improve sleep and quality of circadian rhythm and supporting that DNA. So one of my favorite regenerative products, think about it as like a nightly cellular reset to pursue healthy aging. It's usually done as pulses throughout the year, and we usually do about three of them throughout the year. So we usually do three of them throughout the year. And those three will actually help to reset over the long period of time. So it'll actually work for longer periods. It's not just working while you're actively taking it. So we usually cycle it couple times, twice, two, two weeks at a time, three times a year, something like that. We also think that it's great for promoting vitality and actually recovery for exercise. So doing the epitalon intermittently, if you're training for a long race, because we want to get rid of the toxins that the body is building up with, especially endurance training. Epitalin is really good for kind of doing that reset. Okay. And that's what I would say was one of my favorites for longevity. So you're asking me what to do for overall health, like prevent disease, preventing kind of what we would call diseases of old age, things like different dementias and things that occur with buildup of cellular debris. This is one of them.
All right, let's go to two that are a little bit more brain related.
One is called dip, Deep sleep inducing peptide. And dip is a neuropeptide that it was. It's in the hypothalamus, so it actually is naturally occurring and it de. It restores deep sleep, so it helps the body actually stabilize that stress response.
So perimenopausal women, my anxious people that just can't get their brains to shut off at night, where progesterone maybe isn't cutting it, it actually is a little bit of a stronger GABA stimulator than progesterone. It decreases what we would call the corticotropin release. So that night reduces that nighttime cortisol release.
So we want cortisol, that stress hormone, to go up in the morning and go down as the day goes on.
When it doesn't do that, that cortisol actually, if it spikes at inappropriate times throughout the day, it can keep you awake and it can keep you racy, especially if you're anxious. Who knows what came first, the chicken or the egg, right?
So D SIP actually will help to modulate that, decrease that cortisol response at night so you get a bigger or better deep wave sleep. So we all know that that REM sleep or that deep wave sleep is so important. This will help you get there, supporting recovery and growth hormone release overnight. So again, growth hormone, that master peptide, we want to make sure that it's around as long as possible, especially for that peak overnight sleep and recovery phase. This will help it get there and then it's really good for anxiety. I do combine this with our next peptide, which is specifically for brain and anxiety and mental clarity. But we think that the D SIP actually helps to improve resiliency of the brain to actually not get this perpetuated anxious feeling. So, but like I said, perimenopausal women, D SIP can be life changing, especially when you can't fall asleep and progesterone is just not cutting it, Which I do have a handful of women who the progesterone either is not enough or they just can't tolerate high enough levels for whatever reason, whether they get too sleepy during the day, whether it creates too much breast tenderness, whether they're just not there yet menopausally and they're still making a decent amount of progesterone, but it's irregular.
So you never know what, how much you're going to have on a given Day This D sip is really really nice.
All right, let's talk about this last one. One of my favorites is called C Max or Celanx is another term.
It is a piece of acth and ACTH is basically kind of a hormone that's really high up on our pathway. When we think about growth hormone being a master regulator of all of our other hormones, ACTH is a byproduct as well and it actually enhances this little fragment. This CTH enhances brain derived neurotrophic factor and helps with neuro protection.
So why is that important?
Increased dopamine balances serotonin. When we do these two things, we help with anxiety, mood and clarity. We also boost oxygen metabolism and antioxidants in the brain. So you're able to actually reverse oxidative damage or maybe poor oxygenation. So if there is some microvascular issue, this is actually a good way to help with that too. So if someone has microvascular disease, history of stroke, this can actually help to enhance blood flow to the area as well and help with healing and recovery as well as clarity. So focus, memory, motivation. So someone is feeling demotivated and not so apt to go and maybe go to the market anymore or go do the things they used to like to do.
This sound like is a really great add on for them. It protects those neurons, like I said, from actually getting oxidative stress. So for someone who has my microvascular disease or is prone to any kind of neurodegeneration, Alzheimer's, dementia, this cell anch or C Max has been a really good add on. There's actually lots of good data for it as well. This is another really cool one. ADHD helps with focus. So much so that it's really good for adult ADHD and brain fog. So the women that are complaining about brain fog with menopause, this is a really good one. It helps to actually calm the brain down, give that clarity and focus. So I personally think it' one of the most under the radar nootropics peptides helps to restore cognitive sharpness, especially your type A high stress professionals post Covid long hauler brain. Other bug brain where your brain just can't focus, you just don't have that mental clarity. The xelink is an excellent, excellent add on and it can be taken regularly. So this doesn't have to be necessarily pulse dosed. This can be taken kind of on an ongoing basis.
And it's not like something that you necessarily get used to either meaning like some of the SSRIs or medications on the market, you don't always need more of it. So you can stay at a pretty level steady dose just to contribute to that overall brain calming effect.
Enhanced blood flow. It actually helps to support the immune system too. There is some data to say that it helps to suggest, helps to suggest that reducing inflammation also helps with this particular peptide. And it's very, very safe. Does increase anx anxiety. Anxiety doesn't create increased depression because it's really just stimulating the body to balance your neurotransmitters to alleviate stress.
It can be taken as well with SSRIs. I have seen it done together, but it doesn't have any sedating effects like some of the SSRIs would. So for some of your medications on the market that traditionally would kind of feel, make you feel flat or even kind of just sedated or just, just way too even this doesn't have that effect.
And guys, you can stack these. I think the most interesting thing about peptides is that they can be stacked on top of each other. So for example, AOD 9604, fat metabolism. And then let's get like the menopausal female, for example, throw on C max for mental drive combination and calming down the brain and mood. Epitalon and D sip, right? So we can get some mitochondrial help, DNA help, sleep help so that we can help rest and recover. So we can do those together. You could do all four together. But the great part about this is they are very synergistic.
A really cool one that we haven't talked much about yet is nad. NAD is great for energy levels, mitochondrial repair, detoxing those cells and actually giving you ATP or energy to do your daily activities. We'll talk more about nad. But NAD can be combined with any one of these, especially epitalon or even some other mitochondrial cofactors, which we can talk about in our next podcast for deeper recovery. So, you know, again, if we're working out a lot, if we just want to detoxify, if we have a long term bug or our energy levels are just down, we really want to work on those little cellular powerhouses of our cell which are the mitochondria, and start working with things that improve nad.
Clean things out from your mitochondria, maybe use some epitalon with that and actually start to make some more ATP, which is our energy driver of our body, right? So I think the really important thing is these don't have to work in isolation. They can work together like the ones that we talked about in our last podcast, which was the growth hormone stimulators. They're fabulous. You can use that even with some of these. So. So just because they work a little bit differently doesn't mean they can't be stacked together.
Also, the PT141 for sexual performance and libido, you could mix with some of your, let's just say your mental one, let's say C Max, for example, or Celan, calm the brain down. Get a female out of her head so that she's not constantly thinking during intercourse, especially if she's super anxious, and then get her on some PT141 for libido help is a really great combination. So, again, these don't have to be taken in isolation. They're really great as a stat. And we can alternate them throughout the year. So, for example, like we talked about, that epitalon can be taken two or three times throughout the year as a boost for your body to basically clean out those mitochondria and actually help that DNA to stay nice and elongated, those tails to stay nice and long, those telomeres. So if you're curious about what these peptides, how they could fit into your life, into your personal wellness or longevity plan, if you're already in a program with us and you're not using peptides and you want to consider adding them onto your program, it is very, very simple. Just reach out to us, send a message through our portal if you're a patient. If not, you can send it right through infoydoctorlori.com and just send us a message and say, hey, how can I get started today? Just remember that aging isn't about stopping the clock. It's about optimizing how well you live while it ticks. Which is why we say age your way. It's all about how you want to feel and how you want to age. So please feel free. If you like this podcast, please follow us, share it with a friend. We would be happy to get husbands and wives together on the same journey to wellness. It's probably one of the most common things in my practice. And obviously share us with anyone that you think that could use this information.
